What Are Polynucleotides? Natural Skin Repair Explained
Understanding Polynucleotides and Their Role in Natural Skin Repair
Polynucleotides are gaining attention in the world of non-surgical aesthetics—and for good reason. Known for their regenerative effects and natural-looking results, these treatments are a powerful option for clients who want to improve skin quality without volume enhancement.
At DA Aesthetics in Buckinghamshire, we offer polynucleotide treatments to help rejuvenate the skin at a cellular level—ideal for clients seeking natural results that still deliver visible improvements.
What Is Polynucleotide Treatment?
Polynucleotides are DNA fragments derived from salmon or trout, purified and formulated for medical-grade skin regeneration. When injected into the skin, they help repair tissue, stimulate fibroblasts, and promote the production of collagen and elastin.
Unlike traditional fillers, polynucleotides do not add volume. Instead, they encourage the skin to regenerate from within—making them an ideal choice for clients who want a subtle, natural-looking glow.
How Does Polynucleotide Treatment Work?
Polynucleotides work through biostimulation, a process that activates the skin’s natural repair functions. After injection into the targeted area—such as under the eyes, neck, or face—the treatment promotes:
- Fibroblast proliferation (for collagen production)
- Antioxidant activity (to fight free radicals)
- Improved tissue hydration and elasticity
- Skin repair and reduction of micro-inflammation
Because the formula is non-volumising, the results develop gradually and look incredibly natural.
Polynucleotides vs Skin Boosters
While both treatments aim to revitalise tired, dehydrated skin, they work differently:
Feature | Polynucleotides | Skin Boosters |
Primary Function | Tissue regeneration | Hydration |
Key Benefit | Repairs at a cellular level | Plumps and hydrates |
Result Timeline | Result Timeline | More immediate |
Best For | Fine lines, skin healing | Dehydrated or dull skin |
If you’ve tried skin boosters and want to go one step further in terms of skin renewal and anti-inflammatory effects, polynucleotides may be a better match.
Polynucleotides vs Skin Fillers
This is where the difference is even more distinct. Polynucleotides are not volumising fillers.
Feature | Polynucleotides | Dermal Fillers |
Primary Function | Cell regeneration | Volume enhancement |
Ingredients | Purified DNA fragments | Hyaluronic Acid |
Application | Skin quality, healing | Cheeks, lips, jawline |
Outcome | Natural, subtle glow | Defined contours |
Clients who are hesitant about altering their facial structure or want to focus on improving skin texture often prefer polynucleotides as a natural skin filler alternative.
What Are the Benefits of Polynucleotide Treatment?
Polynucleotides offer a wide range of regenerative benefits, including:
- Smoother, firmer skin texture
- Reduction in fine lines and wrinkles
- Improved hydration and elasticity
- Brighter, more even skin tone
- Faster skin healing post-treatment
- Ideal for delicate areas like under the eyes
- Smoother, firmer skin texture
These treatments are especially popular among clients looking for a preventative ageing solution that doesn’t involve major changes in appearance.
Are There Any Side Effects of Polynucleotides?
Polynucleotide treatments are considered very safe when administered by qualified medical professionals. However, like any injectable procedure, there may be minor, temporary side effects such as:
- Mild swelling at the injection site
- Redness or slight bruising
- Tenderness for 1–2 days
- Mild swelling at the injection site
At DA Aesthetics, we carry out a full in-person consultation to assess suitability, review medical history, and discuss potential polynucleotides side effects before proceeding.
Why Choose DA Aesthetics for Your Polynucleotide Treatment?
At DA Aesthetics, you’re in the care of an experienced medical practitioner. Devie Shaw, our founder, is a Registered Nurse and Independent Nurse Prescriber with over 14 years of clinical experience in both NHS and aesthetic settings.
We prioritise:
- In-depth, face-to-face consultations
- Evidence-based treatment planning
- Safe, ethical practice in line with NMC and ACE guidelines
- Natural-looking results that restore—not alter—your features
- In-depth, face-to-face consultations
Whether you’re considering polynucleotides for under-eye rejuvenation or overall skin repair, you can trust our nurse-led aesthetic clinic in Buckinghamshire for a personalised, professional experience.
Final Thoughts
Polynucleotides offer a subtle but powerful way to support skin repair and rejuvenation from within. Whether you’re new to injectables or looking for a more natural alternative to fillers, this treatment delivers results that look and feel like you—just fresher.
Frequently Asked Questions (FAQs)
No, skin boosters hydrate the skin, while polynucleotides stimulate deep tissue regeneration.
No. They improve skin quality without changing facial structure.
Most clients describe the treatment as mildly uncomfortable. Numbing cream can be used if needed.
Typically, 2–3 sessions spaced 3–4 weeks apart, with maintenance every 6–9 months.
Yes. They’re especially effective in delicate areas like the under-eye zone where skin is thin.